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R1487 (Hydrochloride)
CAS No. 449808-64-4
R1487 (Hydrochloride)( —— )
Catalog No. M20680 CAS No. 449808-64-4
R1487 (Hydrochloride) is an orally bioavailable and highly selective inhibitors of p38α.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 61 | In Stock |
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| 5MG | 96 | In Stock |
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| 10MG | 494 | In Stock |
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| 25MG | 806 | In Stock |
|
| 50MG | 1132 | In Stock |
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| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameR1487 (Hydrochloride)
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NoteResearch use only, not for human use.
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Brief DescriptionR1487 (Hydrochloride) is an orally bioavailable and highly selective inhibitors of p38α.
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DescriptionR1487 (Hydrochloride) is an orally bioavailable and highly selective inhibitors of p38α.
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In VitroR1487 Hydrochloride exhibits IC50 values of 10 nM for p38α inhibition and 200 nM for the inhibition of TNFα induced production of IL-1β.R1487 (Compounds 2a) inhibits production of TNFα by human monocytic cells (THP-1) and inhibits production of IL-1β in human whole blood (HWB) induced by LPS.
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In VivoR1487 (Compounds 2a, orally) demonstrates significant dose-dependent inhibition of serum TNFα and IL-1β.Oral bioavailability of 10 mg/kg R1487 (Compounds 2a) in monkey, rat, and dog was 51.6%, 29.3%, 10.3%, respectively.
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Synonyms——
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PathwayMAPK/ERK Signaling
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Targetp38 MAPK
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Recptorp38α
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Research Area——
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Indication——
Chemical Information
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CAS Number449808-64-4
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Formula Weight424.83
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Molecular FormulaC19H19ClF2N4O3
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Purity>98% (HPLC)
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SolubilityDMSO:20.83 mg/mL (49.03 mM)
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SMILESCl.Cn1c2nc(NC3CCOCC3)ncc2cc(Oc2ccc(F)cc2F)c1=O
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Chemical Name6-(24-difluorophenoxy)-8-methyl-2-(oxan-4-ylamino)pyrido[23-d]pyrimidin-7-one hydrochloride
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Goldstein DM Soth M Gabriel Tet al.J Med Chem. 2011 Apr 14;54(7):2255-65.
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